Abstract

New Spectrophotometric Method for the Estimation of Pantoprazole in Bulk and Pharmaceutical Formulation

Author(s): N. V. Pimpodkar, R. S. Nalawade , B. S. Kuchekar, N. S. Mahajan and R. L. Jadhav

A simple, sensitive, rapid and accurate colorimetric method has been developed for the estimation of pantoprazole in bulk and pharmaceutical dosage forms. This method is based on oxidative coupling reaction of pantoprazole with 3-methyl-2-benzathiazoline hydrazone (MBTH) in presence of ferric ammonium sulphate producing orange red colored chromogen, which exhibits absorption maximum at 504 nm. It obeyed Beer’s law in concentration range of 10-90 μg/mL. The results obtained with the proposed method are in good agreement with labeled amounts, when marketed pharmaceutical preparations are analyzed. Results obtained are statistically validated and found to be reproducible.


Share this