Abstract

New Facile and Sensitive Methods for the Estimation of Telmisatran

Author(s): Y. Kranti Kumar, K. Vanitha Prakash and Guthi Lavanya

Two simple, accurate, rapid and sensitive Methods (A and B) have been developed for the estimation of Telmisatran in its pharmaceutical dosage form. The method A is based on the formation of yellow colored chromogen, due to reaction of Telmisatran with Alizarin red dye. The formation of ion association complexes of the drug with dyes in acidic phthalate buffer of pH 2.8 was followed by their extraction in chloroform, which exhibits λmax at 423 nm. The method B is based on the formation of golden yellow colored chromogen due to reaction of Telmisatran with Bromophenol blue dye. The formation of ion association complexes of the drug with dyes in acidic phthalate buffer of pH 2.8 was followed by their extraction in chloroform, which exhibits λmax at 416 nm. The absorbance-concentration plot is linear over the range of 100- 150 mcg/mL for method A and 20-50 mcg/mL for method B. Results of analysis for all the methods were validated statistically and by recovery studies. The proposed methods are precise, accurate, economical and sensitive for the estimation of Telmisatran in bulk drug and in its tablet dosage form.


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