Four weed plants were screened for medicinally important secondary metabolites. 70% methanol extract and water decoction dissolves maximum components i.e. moderately polar glycosidic components. Presence of coumarins, Flavonoids, Lignan, Phenolic acids, Essential oils, triterpenes was observed almost in all samples. But there are variations in the amount and number of bands in each sample. For their preliminary detection and optimization of separation conditions, TLC method was used and further confirmation was done using HPTLC techniques.