The objective of this research was to determine: 1) the individual acute toxicity of cadmium and chromium on E. fetida by filter paper contact test and soil expose test; 2) the avoidance response of E. fetida; 3) the combined toxicity of cadmium and cadmium on E. fetida in lou soil. The site to collect soil is a lou soil experimental plot northwest A&F university of Yangling, Shaanxi, China. It was shown that the toxicity of cadmium and chromium through skin in nature soil are moderately (200~2000 mg·kg–1). when Cd and Cr were the same concentrations, avoidance rate under Cd pollution is lower than under Cr pollution. It is also concluded that the interaction type of Cr and Cd combined toxicity is antagonistic.