Latent HIV infection needs a life-long antiretroviral treatment, as there is no means to completely eradicate the virus. Therefore, to manage this condition, new approaches should be developed. This article highlighted the results of molecular and proteomic studies that can be used in identifying viral reservoir cells to destroy viral shelter, which might lead to complete viral eradication. Further, administration of engineered HIV resistant autologous hematopoietic stem cells will prevent subsequent infection by exacerbating reminiscent HIV virus. However, problems and limitations in the technology to provide resistant cells still needs to be solved.