A semi-organic nonlinear crystal L-histidine methyl ester dihydrochloride, an analog of L-histidine has been grown successfully by slow evaporation solution growth method at room temperature. The grown crystal was characterized by crystalXRD and FT-NMR studies. The optical transmittance of the grown crystalwas analyzed byUVvisNIR spectral study which shows that the crystal has a wide transmittance windowin the entire visible region. The surface morphology of the grown crystal was analyzed by HR-SEM analysis. The second harmonic generation of the grown crystal was tested by the powder technique of Kurtz and Perry. The thermal stability of the crystal was ascertained by differential scanning calorimetry (DSC) technique. The Vickers microhardness test was performed and the load dependence hardness was estimated.