Oxidative stress and inflammation are linked pathophysiological conditions that have a major role in many chronic disease. Recently, agents with antioxidant activity have been implicated in the development of new therapeutic strategies. Therefore, it seems that management of oxidative stress by agents with antioxidant capacity may have a positive therapeutic effect on chronic diseases including disorders associated with inflammation. Based on recent researches biosynthesized silver nanoparticles (Ag-NPs) seem to have the potential to ameliorate inflammation and oxidative stress. In this regard, evidences from recent researches on the anti-inflammatory mechanism of the biosynthesized Ag-NPs are discussed here.