Evaluation of Antiinflammatory and Analgesic Activity of Ceasalpina Pulchiremma Swartz in Experimental Animals

Author(s): K. V. Ramana, Ch. Narasimha Raju Bh and Ch. V. Rao

Ceasalpina Pulchiremma swarts (FAM caesalpinaceae) popularly known as Peacock flower is well known for its diverse medicinal uses. It is an exotic, hardy, drought resistant shrub and is a striking ornamental plant widely grown in tropical gardens. It is also the country flower of the Caribbean island, Barbados. In India, it is found in the tropical rain forests. It is reported in the literature to be used as a remedy for intestinal worms, cough, and inflammation. The juice from the flowers is well known to cure sores. It is usually prescribed in bronchitis, asthma and malarial fever. In the present study, an attempt has been made to evaluate the antiinflammatory and analgesic activity of the chloroform and methanolic extract of the flowers on rational basis against standard drugs ibuprofen and pentazocin by carrageen induced rat paw edema method; tail flick method by analgesia in albino rats, mice by using the dose levels of 100 mg/kg and 200 mg/kg body weight. A significant activity (P < 0.01 to P < 0.001); antiinflammatory and analgesic activity was observed in the above models as compared to control. The present study indicates that Caesalpina pulchiremma floral extracts has potential antiinflammatory, and analgesic activity. The percentage inhibition of paw oedema and analgesia observed by the methanolic extract was found to be higher than the chloroform extract.

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