Cannabis is the illicit drug most used in the world. This study aimed to assess the adverse effects related to the use of cannabis notified at the MoroccanAnti Poison and Pharmacovigilance Center, between 2008 and 2013. This is a retrospective study over a period of 6 years, ranging from 2008 to 2013 cases of adverse reactions by Cannabis reported to the Moroccan Anti Poison and Pharmacovigilance Center. During the study period, 58 cases have been collected in Moroccan Anti Poison and Pharmacovigilance Center, with a mean of 10 ± 5.18 cases per year. The sex ratio was (M / F) of 3.5 (p <0.001). The mean age was 21.19 ± 1.09 years. The age group most affected age group was that of adults (p <0.001), with 74.1% of cases, followed by adolescents (24.1%) and children with 1.8% of cases. The most affected systems were: Psychiatric disorders, Central and periphique nervous system disorders in 25,7 % of cases for each of them, Gastro-intestinal system disorders (18,8%). The causal relation imputability method according to the WHO, was possible in 61% of couples, certain in 32%, probable within 6% and 1% was unknown.