The current study pertained to tebuconazole (TEB) toxicity in liver of adult mice and the corrective effects of selenium (Se). Male Wistar rats were divided into three groups of six each: group I served as control; group II received by intraperetoneal injection TEB alone (100 mg/Kg b.w), and group III was administered both TEB and Se (0.5 mg/kg of diet) for 30 days. Results showed that, in the TEB-treated group, antioxidant enzyme activities (superoxide dismutase and catalase), lipid peroxidation, advanced oxidation protein product, and protein carbonyl groups levels significantly increased, while glutathione peroxidase activity decreased. Se co-administration through the rats’ diet restored these parameters to near normal values. Treatment with TEB induced various histological changes in the liver, including leucocytic infiltration and cytoplasmic vacuolization, while treatment with TEB and Se led to an improvement in the histological liver picture. Our investigation revealed, therefore, that Se was effective in preventing TEB-induced hepatotoxicity.