Many patients find it difficult to swallow tablets and hard gelatin capsules and thus not comply with prescription that results in high incidence of non-compliance and ineffective therapy. Immediate release tablets are gaining prominence as new drug delivery systems. These dosage forms dissolve or disintegrate in oral cavity within a minute without the need of water or chewing. In this study, an effort has been made to formulate immediate release tablets using different disintegrants drug. Considering the merits of Dasatinib, we are proposing to choose it as an anticancer drug.