To study the dissipation behaviour of Copper oxychloride and Kasugamycin in acidic, neutral and basic water of pH 4.0, 7.0 and 9.0, a laboratory experiment was conducted by the Department of Chemistry, Krishna University,Machilipatnam,Andhra Pradesh. Required quantity of Copper Oxychloride 45%+ Kasugamycin 5%WP formulation, was spiked in pH 4.0, 7.0 and 9.0 aqueous buffer solutions to give uniform concentrations of T0 ÂÂ Untreated Control, T1 ÂÂ Copper Oxychloride 45% + Kasugamycin 5% WP @ 1.0 µg/mL and T2 ÂÂ Copper Oxychloride 45% + Kasugamycin 5% WP @ 2.0 µg /mL. The sampling occasions are 0, 1, 3, 5 and 7 days for Copper oxychloride and 0, 6, 12, 24 and 48th hour for Kasugamycin. Samples collected on different occasions were analysed for Copper oxychloride and Kasugamycin content. Samples were analysed until the residues are below detectable level. All the samples were processed and analysed for the residues by a validated pectrophotometric method for Copper oxychloride and Kasugamycin was analysed by a validated HPLC-UV method. The DT50 (Half Life) of Copper oxychloride and Kasugamycin calculated by regression analysis from the dissipation data.