C-reactive protein (CRP) is an acute phase substance, produced in hepatocytes. It appears in sera of Pneumonia patients and also occurs in some other pathological conditions. The present study investigated 100 childrens between the age group of 1 day - 12 years. In this study 52% were males and 48% were females. All the patients were suspected clinically to have either sepsis or fever or both. The CRP levels were found to be positive in 46.43%of children clinically diagnosed to have sepsis, themaximumrange of CRP was greater than or equal to 48mg/L. In children with fever 40%of the cases were positive while the maximumrange was only greater than or equals to 6mg/L.