A Five week-old Sokoto Gudali calf weighing 25kg was presented to the Large Animal Unit of the Veterinary Teaching Hospital, Usmanu Danfodiyo University, Sokoto with the complaint of inability to stand on its own noticed since birth, history further revealed that the calf only suckled when assisted. It was fed on milk and water only. The dam is the only animal kept by the client. The calf has been given oral glucose two weeks prior to presentation without any improvement. Bacteriology isolation and identification revealed E. coli from the fecal samples. The packed cell volume (PCV), Haemoglobin (Hb) and Total erythrocytes count (TEC) were 55%, 18.3 and 13.2 indicating polycythemia. Neutrophilia and Monocytosis were also observed. Unfortunately, the calf died before any intervention and the carcass was sent to necropsy room for post-mortem examinations.