To observe the clinical efficacy of Huxinkang Tablet on unstable angina pectoris (UAP). 65 patients ofUAPwere divided into the control group (32 cases) and treatment group (33 cases). All patients were treated with the westernmedicine. Then, patients in the control group and treatment group were administered Tongxinluo Capsule and HuxinkangTablet, respectively. The changes of clinical efficacy, angina pectoris (AP), electrocardiograph (ECG), Chinesemedicine syndrome (CMS), blood fat, homocysteine (Hcy) and high-sensitivity C-reactive protein (hs-CRP) of two groups were observed. Total effective rate of the treatment group was higher than the control group (P<0.05). The treatment group had a better curative effect of AP, ECGand CMS than the control group (P<0.05). HuxinkangTablet had better effects to improve lipid metabolismand lower the levels of Hcy and hs-CRP than the control group (P<0.05). It is effective that the clinical efficacy of Huxinkang Tablet in treating UAP.