Clerodendron Inerme L belonging to family Verbenaceae is very widely distributed in tropical and subtropical regions of the world and is comprised of small trees, shrubs and herbs. Ethno-medicinal importance of various species of Clerodendron genus has been reported in various indigenous systems of medicine and as folk medicines. Different parts of this plant are traditionally claimed to be used for the treatment of cough, skin rashes boils and fever. They are also used to treat umbilical cord infection and for cleaning uterus in local medicine. There has been a tremendous interest in this plant as evidenced by the voluminous work in last few decades. Therefore, It has been aimed to compile an up to date and comprehensive review of Clerodendron Inerme that covers its traditional and folk medicine uses, phytochemistry and pharmacology including various preclinical and clinical studies.