Cefpodoxime proxetil is an orally administered broad spectrum third-generation cephalosporin. It is a pro-drug that is de-esterified in-vivo to cefpodoxime, which has potent antibacterial activity. It is generally well tolerated and demonstrates good therapeutic potential in patients with various common bacterial infections. This compound has been used most widely in the management of infections of the respiratory and urinary tracts as well as those of the skin structure, acute otitis media, pharyngitis, tonsillitis etc. The present article describes pharmacology, pharmacokinetics, clinical aspects, adverse effects and interactions of cefpodoxime proxetil. Special emphasis is also laid on the determination of cefpodoxime proxetil in pharmaceutical dosage forms and biological fluids by employing different advanced analytical methodologies.