The whole plant of the methanolic extract from Leucas Cephalotes was screened for in vitro antioxidant (using DPPH method), analgesic (using hot plate test in mice) and anti-inflammatory (using rat paw edema test) activity at the doses of 200 and 400mg/kg. Themethanolic extract of Leucas Cephalotes (MELC) has scavenged the DPPH radicals in a dose dependent manner. The IC50 value to scavenge DPPH radicals was found to be 427.3µg/ml. A significant (p<0.0005) analgesic activity was observed at 60 min with 200 mg/kg and 400 mg/kg has exhibited maximum activity. The maximum anti-inflammatory response was produced at 3 hr and 2 hr with doses of 200 and 400 mg/kg respectively. These results suggest that the methanolic extract Leucas Cephalotes has exhibited significant analgesic and anti-inflammatory effects, whichwere comparablewith standard drugs.