Calotropis gigantea linn is a perennial shrub, commonly known as milkweed or wasteland weed. It belongs to family Asclepiadaceae and was evaluated for its anticonvulsant activity. The leaves were extracted with 70% ethanol and concentrated to obtain residue. The hydro-alcoholic extract (HLE) at a dose of 400 mg/kg b.w, 300 mg/kg b.w, 200 mg/kg b.w and 100 mg/kg b.w by i.p route were tested for their anticonvulsant property against Maximum Electric Shock (MES) induced convulsion model in Swiss albino mice of either sex weighing between 18 g -22 g. A significant (p < 0.01) anticonvulsant activity had been observed in the HLE (400 mg/kg b.w and 300 mg/kg b.w) followed by HLE (200 mg/kg b.w and 100 mg/kg b.w) when compared to control group. Phytochemical screening reveals the presence of alkaloids, cardiac glycosides, flavonoids, steroids, tannins, triterpenoids, carbohydrates and saponins in the hydroalcoholic leaf extract of Calotropis gigantea linn.