Irrigation with wastewater alleviated the shortage of agricultural water resources at the same time, also caused series of environmental security issues. The groundwater was polluted, farmland was polluted by some heavy metals and toxic substances), the quality and yield of agricultural products reduced in some irrigation zones. All of those will affect human health severely. The effective ways to improve the safety of sewage irrigation is to push forward the pretreatment technology of sewage, to promotion of irrigations with reclaimed water and to combine sewage treatment technology with suitable irrigation ways. Through these measures, the safe use of sewage recycle treatment will be realized, the ecological environment will be improved, and the food security will be ensured.