Primary liver cancer (PLC) is one of the common malignant tumors. With high incidence and poor prognosis, PLC has become one of the major diseases which is seriously harmful to human life and health. In recent years, the research work have been summarized on the status of the treatment of primary liver cancer, and great progress has been made, especially the significant progress in the early diagnosis, surgical treatment, and comprehensive treatment of liver cancer made to improve the quality of life of patients. In spite of many methods can be used to improve the quality of life, there are still issues need to be studied deeply. The overview of the progress in the therapy research of liver cancer had been done in this paper that may provide assistance for the further treatment of such disease.