Genomics is an endeavor term 10 years ago which is achieving momentum across the entire clinical continuum from risk assessment in healthy individuals to genome-guided treatment in patients with complex diseases. The review process is going on the latest achievements in genomic research and their significance on modern system of medicine, primarily in the past decade. Advances in technology have enabled the development of genomic tools that are responsible for transformation not only the science of medicine but also the health care application. The importance of genomics includes cancer pharmacogenomics, in the diagnosis of rare disorders, and in the tracking of infectious disease. The function of genetics in medical science is extending in high manner, single-gene disorders is beginning to complete many areas of medical science across primary and specialty care.