A simple, sensitive, accurate and economic method has been developed for the quantitative estimation of cisapride in bulk drugs and its formulations. The method is based on the reaction of the drug in methanolic solution with vanillin in acidic condition producing Schiff’s base having a absorption maximum at 410 nm. Beer’s law is obeyed in concentrations ranging from 20-100 μg/mL. The results obtained with the proposed methods are in good agreement with labeled amounts when the marketed pharmaceutical formulations are analyzed. The results of analysis have been validated statistically and by recovery studies.