|
P Muthukumaran1, John M Dar2, Imran A Dar3,
Kalaiyarasan1
1Department of Siddha Medicine, Tamil university, Tamil
Nadu, Thanjavur- 613010
2Dyp. Superintendent- Kashmir Tibiya College, Research center
and hospital- Srinagar.
3Department of Industries and Earth Sciences, Tamil
university, Tamil Nadu,
Thanjavur- 613010 |
|
This study quantified the
protective role of propolis on mercuric chloride induced neurotoxicity
in the brain tissue of rats, Rattus norvegicus. Mercury poisoning
induced oxidative stress leading to generation of free radicals and
simultaneous alterations in antioxidant mechanism in animals. In the
present research, the level of lipid peroxidation (LPO) was increased in
the brain tissue of rats at sub-lethal dose of mercuric chloride (2 mg/
kg body wt.) treatment for 30 days; and simultaneously decreased level
of glutathione (GSH), glutathione peroxidase (GPx), catalase (CAT) and
superoxide dismutase (SOD) contents were also noticed in the mercury
intoxicated brain tissue. During the recovery period an altered level of
antioxidant status was restored to near normal level in the brain tissue
of mercury intoxicated animal, when treated with propolis (200 mg/ kg
body wt.) for another 15 days. Stastical significance was evaluated
using ANOVA followed by Duncan Multible Range Test (DMRT). The analysis
of the results showed that the Propolis play a vital role to detoxify
mercury toxicant in the mercury intoxicated animals. |
