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Subhaschandra M.Gaddad*, Muzaheed, Channappa T.Shivannavar
Department of Microbiology, Gulbarga University, Karnataka, (INDIA)
Department of Microbiology, Gulbarga University, Gulbarga, 585106,
Karnataka, (INDIA) |
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Background and objective:
Extended-Spectrum beta-Lactamase (ESβL) producing bacteria may not be
detected by routine disk diffusion susceptibility test, leading to
inappropriate use of antibiotics and treatment failure. Current
knowledge on antimicrobial susceptibility pattern is essential for
appropriate therapy. Here we report the incidence and resistance pattern
of ESβL producing Klebsiella pneumoniae clinical isolates
recovered in Southern India. Methods: A total of 286
Klebsiella pneumoniae were isolated from 1372 clinical samples.
Antimicrobial susceptibility was determined by Kirby-Bauer’s disc
diffusion method. All isolates were screened for ESβL production
according the Clinical Laboratory Standards Institute. Results:
Of the 286 K.pneumoniae isolates, 275 (96.15%) were positive for
ESβL production. Multiple antibiotic resistances were most common and
the majority of the isolates 129 (45.10%) were resistant to as many as
seven antibiotics. All the isolates were sensitive to imipenam.
Interpretation and conclusion: High percentage of drug resistance in
ESβL producing Klebsiella pneumoniae suggests that monitoring of
ESβL production and antimicrobial susceptibility testing are necessary
to avoid treatment failure. |
