In Vitro Transdermal Delivery Of Aceclofenac Sustained Release
Polymer Based Gel Using Wistar Rat Skin
 

M.Mudasir^1*, N.Tabassum¹, J.Ali2, R.Jan^3
1Department of Pharmaceutical sciences, University of Kashmir, Srinagar-190006 (INDIA)
²Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard University,
New Delhi-110062 (INDIA)
³Department of Clinical Biochemistry, Sher-i- Kashmir Institute of Medical Sciences,
Soura, Srinagar-190009 (INDIA)

In vitro percutaneous absorption of Aceclofenac was done in order to assess its feasibility for transdermal development across wistar rat skin and formulating into a sustained release transdermal gels containing penetration enhancers like dimethyl sulfoxide (DMSO). Transdermal gels were prepared using different polymers like carbopol-934, PVA (hot), HPMC-K₄M, HPC-M and SCMC. The formulated gels were subjected to physicochemical studies, in-vitro release studies and in-vitro skin permeations studies. The in-vitro release studies of prepared gels were performed using specially designed Fites cell and in-vitro skin permeation studies were performed using keshary-chien diffusion cell through rat skin. The optimized gel which showed best in-vitro skin permeation of aceclofenac was compared with the marketed formulation and it was found that optimized one (carbapol 934) produced better results in comparison to marketed one.