Investigations On Pharmacologically Important Bivalent Iron
And Tin Macrocyclic Complexes : Antimicrobial Activity
And Modulation Of Radiation Induced Alterations
 

Ashu Chaudhary^1*, D.Kumar¹, R.V.Singh^2
1Department of Chemistry, Banasthali University, Rajasthan-304022, (INDIA)
²Department of Chemistry, University of Rajasthan, Jaipur-302 004, (INDIA)
 

Bivalent tin complexes of macrocyclic ligands have been prepared by the template condensation reactions of 1,10-phenanthroline and different dicarboxylic acids (Malonic, Succinic, Glutaric and Adipic) in the presence of metal ions in 2:2:1 molar ratios. The possibility of potential uses of these complexes as fungicidal and bactericidal studies are discussed. Main emphasis has been given on the protective effect of [Sn(Mac⁸)Cl₂] on radiation induced hematological and biochemical changes in Swiss albino mice.[Sn(Mac⁸)Cl₂] solution was given orally for seven consecutive days prior to radiation exposure. The dose reduction factor (DRF=1.59) for [Sn(Mac⁸)Cl₂] was calculated from LD_50/30 values. The hematological parameters were assessed at different intervals of post-irradiation from day 1 to 30. The average hemoglobin (Hb) level, total erythrocyte count (TEC) and total leucocyte count (TLC) in experimental group were significantly elevated as compared to the control group of animals.[Sn(Mac⁸)Cl₂] significantly elevated reduced glutathione (GSH) level in liver against radiation-induced depletion. Treatment with [Sn(Mac⁸)Cl₂] caused a significant decrease in malondialdehyde (MDA) formation in the liver, suggesting its role in protection against radiation induced membrane and cellular damage. The results of the present study suggest that [Sn(Mac⁸)Cl₂] modulate the radiation induced hematological and biochemical alterations in Swiss albino mice.