Analgesic And Anti-Inflammatory Activity Of Adiantum Venustum
 

M.Mohammed Hussain¹, Pichandy Muthuprasanna³, T.Srinivasarao³, Malarkodi velraj⁴, P.Shanmugapandian², Kannaiyan Suriaprabha^1*
1Department of Pharmaceutics, CL Baid Metha College of Pharmacy,
Chennai-600 096, (INDIA)
²Head of the Department of Pharmaceutical Analysis,
 Viswabarathi College of Pharmaceutical Sciences,Pericherla,
NTR Road Guntur Dist-522 009, (INDIA)
³Department of Pharmaceutics, Vels College of Pharmacy,
 Pallavaram, Chennai-600 117, (INDIA)
⁴Department of Pharmacognosy, Vels College of Pharmacy,
Pallavaram, Chennai-600 11, (INDIA)

Adiantum venustum is a plant belongs to the family adiantaceae. The dried powdered plant material was extracted with ethanol and it showed positive test for flavonoids, alkaloids, saponins and carbohydrates. An attempt was made to correlate the analgesic and anti-inflammatory activity of the crude extract with a standard synthetic drugs - paracetamol (150mg/kg) and Diclofenac sodium (10mg/kg). The analgesic property was evaluated by Eddy’s hot plate method. A good analgesic activity was seen with (100mg/kg) when compared with other dose levels (50mg/kg). Chronic anti-inflammatory study was evaluated by carrageen induced paw edema method. The result of anti-inflammatory study at two dose levels tested in rats, exhibited significant anti-inflammatory activity. The maximum percentage inhibition of inflammation was (71.15%) recorded with 100 mg/kg of plant extract. A further decrease in dose level (50mg/kg) showed decrease in anti-inflammatory activity.